교수, M.D., Ph.D. 연세대학교
  중추신경약리, 신경가소성
  2228-1738
  kimhoon@yuhs.ac
 
 

1. C.H. Kim, and Y.S. Ahn (1997) Nitric oxide prevents the bovine cerebral endothelial cell death induced by serum deprivation. Korean J. Physiol. Pharmacol. 1, 515-521

2. C.H. Kim, J.H. Kim, J. Xu, C.Y. Hsu, and Y.S. Ahn (1999) Pyrrolidine dithiocarbamate induces bovine cerebral endothelial cell death by increasing intracellular zinc level. J. Neurochem. 72, 1586-1592

3. C.H. Kim, J.H. Kim, C.Y. Hsu, and Y.S. Ahn (1999) Zinc is required in pyrrolidine dithiocarbamate inhibition of nuclear factor kappa B (NF-kappaB). FEBS Lett. 449, 28-32

4. C.H. Kim, J.H. Kim, S.J. Moon, K.C. Chung, C.Y. Hsu, J.T. Seo, and Y.S. Ahn (1999) Pyrithione, a zinc ionophore, inhibits NF-kappaB activation. Biochem. Biophys. Res. Commun. 259, 505-509

5. K.C. Chung, J.H. Park, C.H. Kim, and Y.S. Ahn (1999) Tumor necrosis factor alpha and PMA differentially modulate cytotoxic effect of nitric oxide generated by serum deprivation in neuronal PC12 cells. J. Neurochem. 72, 1482-1488

6. C. Choi, J.Y. Park, J. Lee, J. Lim, E. Shin, Y.S. Ahn, C.H. Kim, S. Kim, J. Kim, I.S. Choi, and I. Choi. (1999) FasL and Fas are expressed constitutively in human astrocytes and the expression increases with IL-1, IL-6, TNF-alpha or IFN-gammaJ. Immunol. 162, 1889-1895

7. C.H. Kim, J.H. Kim, S.J. Moon, C.Y. Hsu, J.T. Seo, and Y.S. Ahn (1999) Biphasic effects of dithiocarbamates on the activity of NF-kappaB. Eur. J. Pharmacol. 392, 133-136

8. Y.S. Ahn, C.H. Kim, and J.H. Kim (1999) Role of protein kinases on NF-kappaB activation and cell death in bovine cerebral endothelial cells. Korean J. Physiol. Pharmacol. 3, 11-18

9. K.C. Chung, J.H. Park, C.H. Kim, H.W. Lee, N. Sato, Y. Uchiyama, and Y.S. Ahn (2000) Novel biphasic effect of pyrrolidine dithiocarbamate on neuronal cell viability is mediated by the differential regulation of intracellular zinc and copper ion levels, NF-kappaB and MAP kinases. J. Neurosci. Res. 59, 117-125

10. S. Baek, J. Kim, J. Choi, E. Park, M. Han, C.H. Kim, Y.S. Ahn, and Y. Park (2000) Reduced glutathione oxidation ratio and 8 ohdG accumulation by mild ischemic pretreatment. Brain Res. 856, 28-36

11. E.C. Shin, J.M. Ahn, C.H. Kim, Y. Choi, Y.S. Ahn, H. Kim, S.J. Kim, and J.H. Park (2001) Interferon-gamma induces cell death in human hepatoma cells through a TRAIL/death receptor-mediated apoptotic pathway. Int. J. Cancer 93, 262-268.

12. E.C. Shin, Y.R. Seong, C.H. Kim, H. Kim, Y.S. Ahn, K. Kim, S.J. Kim, S. Hong, and J.H. Park (2002) Human hepatocellular carcinoma cells resist to TRAIL-induced apoptosis, and the resistance is abolished by cisplatin. Exp. Mol. Med. 34, 114-122

13. C.H. Kim, J.H. Kim, J. Lee, C.Y. Hsu, and Y.S. Ahn (2003) Thiol antioxidant reversal of pyrrolidine dithiocarbamate-induced reciprocal regulation of AP-1 and NF-kappaB. Biol. Chem. 384, 143-150

14. J. Lee, C.H. Kim, K.D. Shim, and Y.S. Ahn (2003) Inhibition of NF-kappaB activation increases oxygen-glucose deprivation-induced cerebral endothelial cell death. Korean J. Physiol. Pharmacol. 7, 65-71

15. C.H. Kim, J.H. Kim, J. Lee, and Y.S. Ahn (2003) Zinc-induced NF-kappaB inhibition can be modulated by changes in intracellular metallothionein level. Toxicol. Appl. Pharmacol. 190, 189-196

16. D.Y. Park, M.Y. Sol, K.S. Suh, E.C. Shin, and C.H. Kim (2003) Expression of transforming growth factor (TGF)-beya1 and TGF-beta type II receptor and their relationship with apoptosis during chemical hepatocarcinogenesis in rats. Hepatol. Res. 27, 205-213

17. I. Kim*, C.H. Kim*, J.H. Kim, J. Lee, J.J. Choi, M.G. Lee, K.C. Chung, C.Y. Hsu, and Y.S. Ahn (2004) Pyrrolidine dithiocarbamate and zinc inhibit proteasome-dependent proteolysis. Exp. Cell Res. 298, 229-238(*equal contribution)

18. C.H. Kim, B. Stephanie, J.T.R. Isaac, and K.W. Roche (2005) Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on serine 839 regulates Ca2+ oscillations. J. Biol. Chem. 280, 25409-25415

19. J.H. Lee, J. Lee, G.H. Seo, C.H. Kim, and Y.S. Ahn (2007) Heparin inhibits NF-kappaB activation and increases cell death in cerebral endothelial cells after oxygen-glucose deprivation. J. Mol. Neurosci. 32(2), 145-154

20. C.H. Kim*, J. Lee, J. Lee, K.W. Roche (2008) Metabotropic glutamate receptors: phosphorylation and receptor signaling. J. Neurosci. Res. 86, 1-10 (*corresponding author)

21. E.S. Kang, G.T. Lee, B.S. Kim, C.H. Kim, G.H. Seo, S.J. Han, K.Y. Hur, C.W. Ahn, H. Ha, M. Jung, Y.S. Ahn, B.S. Cha, H.C. Lee (2008) Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats. Eur. J. Pharmacol. 579, 418-425

22. E.S. Kang, M.S. Kim, Y.S. Kim, C.H. Kim, S.J. Han, S.W. Chun, K.Y. Hur, C.M. Nam, C.W. Ahn, B.S. Cha, S.I. Kim, H.C. Lee (2008) A Polymorphism in the Zinc Transporter Gene, SLC30A8, Confers Resistance Against Posttransplantation Diabetes Mellitus in Renal Allograft Recipients. Diabetes 58, 1043-1047

23. I. Kim*, C.H. Kim*, G.H. Seo, H.S. Kim, J. Lee, D.G. Kim, Y.S. Ahn (2008) Inhibitory effect of zinc on hypoxic HIF-1 activation in astrocytes. Neuroreport, 19, 1065-1068 (*equal contribution)

24. J.H. Lee, J. Lee, K.Y. Choi, R. Hepp, J. Lee, M.K. Lim, M. Chatani-Hinze, P.A. Roche, D.G. Kim, Y.S. Ahn, C.H. Kim*, K.W. Roche (2008) Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5, Proc. Natl. Acad. Sci. USA, 105, 12575-12580 (*corresponding author)

25. I. Kim, C.H. Kim, Y.S. Yim, Y.S. Ahn (2008) Autocrine function of erythropoietin in IGF-1-induced erythropoietin biosynthesis. Neuroreport 19, 1699-1703

26. Y.H. Lee, E.S. Kang, S.H. Kim, S.J. Han, C.H. Kim, C.W. Ahn, B.S. Cha, M, Nam, C.M. Nam, H.C. Lee (2008) Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population. J. Hum. Genet. 53, 991-998

27. J.H. Lee, C.H. Kim, G.H. Seo, J. Lee, J.H. Kim, D.G. Kim, Y.S. Ahn (2008) Heparin Attenuates the _Expression of TNFα-induced Cerebral Endothelial Cell Adhesion Molecule. Korean J. Physiol. Pharmacol. 12, 231-236

28. J.H. Lee, C.H. Kim, D.G. Kim, Y.S. Ahn (2009) Microarray analysis of differentially expressed genes in the brains of tubby mice. Korean J. Physiol. Pharmacol. 13, 91-97

29. J. Lee*, C.H. Kim*, D.G. Kim, Y.S. Ahn (2009) Zinc inhibits amyloid ? production from Alzheimer’s amyloid precursor protein in SH-SY5Y cells. Korean J. Physiol. Pharmacol. 13, 195-200 (*equal contribution)

30. Y.S. Yim, J. Choi, S.B. Jang, G.T. Kim, K. Park, C.H. Kim, J. Cheon, D.G. Kim (2009) Pharmacokinetic properties and tissue storage of FITC-conjugated SA-MnMEIO nanoparticles in mice. Current Applied Physics 9, e304-e307

31. Y.H. Hong, J.Y. Kim, J.H. Lee, H.G. Chae, S.S. Jang, J.H. Jeon, C.H. Kim, J. Kim, S.J. Kim (2009) Agonist-induced internalization of mGluR1? is mediated by caveolin. J. Neurochem. 111, 61-71

32. E.S. Kang, M.S. Kim, C.H. Kim, C.M. Nam, S.J. Han, K.Y. Hur, C.W. Ahn, B.S. Cha, S.I. Kim, H.C. Lee, Y.S. Kim (2009) Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea. Transplantation 88, 693-698

33. Kwon JY, Bai SW, Kwon YG, Kim SH, Kim CH, Kang MH, John AL, Park YW: The effect of nicotine on the production of soluble fms-like tyrosine kinase-1 and soluble endoglin in human umbilical vein endothelial cells and trophoblasts
Acta Obstetricia Et Gynecologica Scandinavica 89/4 :565-571, 2010

34. Choi JY, Kim CH, Kim JY, Ha HJ, Ryu YH: An efficient synthesis of trans-N-{2-[4-(2-Methoxyphenyl)piperazinyl]ethyl} -N-(2-pyridyl)-N-(4-tosyloxymethylcyclohexane)carboxamide, A precursor of [ 18F]mefway for imaging 5-HT1A receptor. Bull Korean Chem Soc 31(8): 2371-2374, 2010

35. Lee JD, Park HJ, Park ES, Oh MK, Park B, Rha DW, Cho SR, Kim EY, Park JY, Kim CH, Kim DG, Park CI: Motor pathway injury in patients with periventricular leucomalacia and spastic diplegia. Brain 134(4): 1199-1210, 2011

36. Lee J, Kim I, Oh SR, Ko SJ, Lim MK, Kim DG, Kim CH: Regulation of DREAM Expression by Group I mGluR. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY 15(2): 95-100, 2011

37. Kim I, Kang ES, Yim YS, Ko SJ, Jeong SH, Rim JH, Kim YS, Ahn CW, Cha BS, Lee HC, Kim CH: A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion. The Pharmacogenomics Journal 11: 191-198, 2011

38. Choi HK, Choi KC, Yoo JY, Song M, Ko SJ, Kim CH, Ahn JH, Chun KH, Yook JI, Yoon HG: Reversible SUMOylation of TBL1-TBLR1 Regulates beta-Catenin-Mediated Wnt Signaling. Molecular Cell 43(2):203-216, 2011

39. Kim IS, Park EJ, Seo JH, Ko SJ, Lee J, Kim CH: Zinc stimulates tau S214 phosphorylation by the activation of Raf/mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase pathway. Neuroreport 22(16): 839-844, 2011

40. Lee J, Yim YS, Ko SJ, Kim DG, Kim CH: Gap junctions contribute to astrocytic resistance against zinc toxicity. Brain Research Bulletin 86: 314-318, 2011

41. Yim YS, Choi JS, Kim GT, Kim CH, Shin TH, Kim DG, Cheon JW: A facile approach for the delivery of inorganic nanoparticles into the brain by passing through the blood-brain barrier (BBB). CHEMICAL COMMUNICATIONS 48(1): 61-68, 2012

42. Yim YS, Lee J, Kim GT, Song T, Kim CH, Kim DG: Hippocampal mGluR5 predicts an occurrence of helplessness behavior after repetitive exposure to uncontrollable stress. Neuroscience Letters 519(1): 62-66, 2012

43. Choi JY, Kim CH, Jeon TJ, Kim BS, Yi CH, Woo KS, Seo YB, Han SJ, Kim KM, Yi DI, Lee M, Kim DG, Kim JY, Lee KC, Choi TH, An G, Ryu YH: Effective MicroPET imaging of brain 5-HT1A receptors in rats with [18F]MeFWAY by suppression of radioligand defluorination. SYNAPSE 66(12): 1015-1023, 2012

44. Choi JY, Kim CH, Jeon TJ, Cho WG, Lee JS, Lee SJ, Choi TH, Kim BS, Yi CH, Seo Y, Yi DI, Han SJ, Lee M, Kim DG, Lee JD, An G, Ryu YH: Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F] FPCIT and [18F] fallypride. APPLIED RADIATION AND ISOTOPES 70(12): 2689-2694, 2012

45. Ko SJ, Isozaki K, Kim I, Lee JH, Cho HJ, Sohn SY, Oh SR, Park S, Kim DG, Kim CH, Roche K: PKC Phosphorylation Regulates mGluR5 Trafficking by Enhancing Binding of Siah-1A. Journal of Neuroscience 32(46): 16391-16401, 2012

46. Yim YS, Kwon Y, Nam J, Yoon HI, Lee K, Kim DG, Kim E, Kim CH, Ko J: Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases. PNAS 110(10): 4057-4062, 2013

47. Lee MY, Yu JH, Kim JY, Seo JH, Park ES, Kim CH, Kim H, Cho SR: Alteration of Synaptic Activity-Regulating Genes Underlying Functional Improvement by Long-term Exposure to an Enriched Environment in the Adult Brain. NEUROREHABILITATION AND NEURAL REPAIR 27(6): 561-574, 2013

48. Jeong YT, Shim J, Oh SR, Yoon HI, Kim CH, Moon SJ, Montell C: An Odorant-Binding Protein Required for Suppression of Sweet Taste by Bitter Chemicals. Neuron 79(4): 725-737, 2013

49. Park HJ, Kim CH, Park ES, Park B, Oh SR, Park CI, Lee JD: Increased GABA-A Receptor Binding and Reduced Connectivity at the Motor Cortex in Children with Hemiplegic Cerebral Palsy: A Multimodal Investigation Using 18F-Fluoroflumazenil PET, Immunohistochemistry, and MR Imaging. JOURNAL OF NUCLEAR MEDICINE 54(8): 1263-1269, 2013

50. Seo JH, Kim H, Park ES, Lee JE, Kim DW, Kim HO Kim, Im SH, Yu JH, Kim JY, Lee MY, Kim CH, Cho SR: Environmental Enrichment Synergistically Improves Functional Recovery by Transplanted Adipose Stem Cells in Chronic Hypoxic-Ischemic Brain Injury. Cell Transplantation 22(9): 1553?568, 2013

51. Moon YJ, Bai SW, Jung CY, Kim CH: Estrogen-related genome-based expression profiling study of uterosacral ligaments in women with pelvic organ prolapse. INTERNATIONAL UROGYNECOLOGY JOURNAL 24(11): 1961-1967, 2013

52. Choi JY, Kim CH, Ryu YH, Seo YB, Truong P, Kim EJ, Choi TH, Kang JH, Lee M, Kim DG, Lee JD, Jeon TJ: Optimization of the radiosynthesis of [F-18]MEFWAY for imaging brain serotonin 1A receptors by using the GE TracerLab FXFN-Pro module. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 56/12 :589-594, 2013

53. Park J, Lee J, Shim JW, Han WS, Lee J, Bae YC, Chung YD, Kim CH, Moon SJ: dTULP, the Drosophila melanogaster Homolog of Tubby, Homolog of Tubby, Regulates Transient Receptor Potential Channel Localization in Cilia.
PLOS GENETICS 9/9 :e1003814-e1003814, 2013

54. Lee M, Ryu YH, Cho WG, Jeon TJ, Lyoo CH, Kang YW, Lee SJ, Kim CH, Kim DG, Kang JH, Seo YB, Yi CH, Lee K, Choi TH, Choi JY: Dopaminergic neuron destruction reduces hippocampal serotonin 1A receptor uptake of trans-[18F]Mefway. APPLIED RADIATION AND ISOTOPES 94:30-34, 2014

55. Kwon O, Kang ES, Kim I, Shin SR, Kim M, Kwon S, Oh SR, Ahn YS, Kim CH: GPR30 mediates anorectic estrogen-induced STAT3 signaling in the hypothalamus 63(11): 1455-1461, 2014

56. Jeong HS, Lee HK, Tark KC, Lew DH, Koh YW, Kim CH, Seo IS: Effect of Endogenous Bone Marrow Derived Stem Cells Induced by AMD-3100 on Expanded Ischemic Flap 29:237-248, 2014

57. Choi JY, Kim BS, Kim CH, Kim DK, Han SJ, Lee K, Kim KM, An G, Choi TH, Yoo SD, Ryu YH: Translational possibility of [18F]Mefway to image serotonin 1A receptors in humans: Comparison with [18F]FCWAY in rodents. SYNAPSE 68/12 68(12): 595-603, 2014

58. Choi JY, Shin SR, Lee MK, Jeon TJ, Seo Y, Kim CH, Kim DG, Yi CH, Lee K, Choi TH, Kang JH, Ryu YH: Acute Physical Stress Induces the Alteration of the Serotonin 1A Receptor Density in the Hippocampus. SYNAPSE 68(8): 363-368, 2014

59. Song J, Kim E, Kim CH, Song HT, Lee JE: The Role of Orexin in Post- Stroke; Emphasizing on Inflammation, Cognitive decline, Depression following Stroke. MOLECULAR BRAIN 8:16-, 2015

60. Song J, Kim E, Kim CH, Song HT, Lee JE: The role of orexin in post-stroke inflammation,cognitive decline, and depression. MOLECULAR BRAIN 8(16): 1-9, 2015

61. Kang JH, Lee M, Ryu YH, Lyoo CH, Kim CH, Lee KC, Choi TH, Choi JY: [18F]FPEB and [18F]FDEGPECO comparative study of mGlu5 quantification in rodent brain. APPLIED RADIATION AND ISOTOPES 98:103-107, 2015

62. Song J, Kang SM, Kim E, Kim CH, Song HT, Lee JE: Impairment of insulin receptor substrate 1 signaling by insulin resistance inhibits neurite outgrowth and aggravates neuronal cell death. NEUROSCIENCE 301: 26-38, 2015

63. Shin SR, Kwon O, Kang JI, Kwon S, Oh SR, Choi J, Kim CH, Kim DG: mGluR5 in the nucleus accumbens is critical for promoting resilience to chronic stress. NATURE NEUROSCIENCE 18(7): 1017-1024, 2015

64. Song J, Kang SM, Kim E, Kim CH, Song HT, Lee JE: Adiponectin receptor 1-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations: an in vivo and in vitro study. CELL DEATH & DISEASE 6: e1844- 2015

65. Lee M, Ryu YH, Cho WG, Kang YW, Lee SJ, Jeon TJ, Lyoo CH, Kim CH, Kim DG, Lee K, Choi TH, Choi JY: Relationship between dopamine deficit and the expression of depressive behavior resulted from alteration of serotonin system. SYNAPSE 69(9): 453-460, 2015

66. Kim MS, Yu JH, Kim CH, Choi JY, Seo JH, Lee MY, Yi CH, Choi TH, Ryu YH, Lee JE, Lee BH, Kim H, Cho SR: Environmental enrichment enhances synaptic plasticity by internalization of striatal dopamine transporters. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 35(9): 1-12, 2015

67. Wang HJ, Park JY, Kwon O, Choi EY, Kim CH, Hur KY, Lee MS, Yun M, Cha BS, Kim YB, Lee H, Kang ES: Chronic HMGCR/HMG-CoA Reductase Inhibitor Treatment Contributes to Dysglycemia by Upregulating Hepatic Gluconeogenesis through Autophagy Induction. AUTOPHAGY 11(11): 2089-2101, 2015

68. Hong SH, Cho JG, Yoon KJ, Lim DS, Kim CH, Lee SW, Park SG: The antibody atliximab attenuates collagen-induced arthritis by neutralizing AIMP1, an inflammatory cytokine that enhances osteoclastogenesis. BIOMATERIALS 44/0 :45-54, 2015

69. Park J, Lee N, Kavoussi A, Seo JT, Kim CH, Moon SJ: Ciliary Phosphoinositide Regulates Ciliary Protein Trafficking in Drosophila. CELL REPORTS 13/13 :2808-2816, 2015

 
 
 
 
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